| ACTIVE | PLAYER | TITLES |
|---|---|---|
| A | Rafael Nadal | 10 |
| A | Novak Djokovic | 6 |
| Thomas Muster | 3 | |
| Jaroslav Drobný | 3 | |
| Marty Mulligan | 3 | |
| A | Alexander Zverev | 2 |
| Ilie Nastase | 2 | |
| Bjorn Borg | 2 | |
| Vitas Gerulaitis | 2 | |
| Andres Gomez | 2 | |
| Ivan Lendl | 2 | |
| Jim Courier | 2 | |
| Nicola Pietrangeli | 2 | |
| Andy Murray | 1 | |
| A | Daniil Medvedev | 1 |
| Tom Okker | 1 | |
| John Newcombe | 1 | |
| Rod Laver | 1 | |
| Manuel Orantes | 1 | |
| Raul Ramirez | 1 | |
| Adriano Panatta | 1 | |
| Guillermo Vilas | 1 | |
| Jose Luis Clerc | 1 | |
| Jimmy Arias | 1 | |
| Yannick Noah | 1 | |
| Mats Wilander | 1 | |
| Alberto Mancini | 1 | |
| Emilio Sanchez | 1 | |
| Pete Sampras | 1 | |
| Alex Corretja | 1 | |
| Marcelo Rios | 1 | |
| Gustavo Kuerten | 1 | |
| Magnus Norman | 1 | |
| Juan Carlos Ferrero | 1 | |
| Andre Agassi | 1 | |
| Felix Mantilla | 1 | |
| Carlos Moya | 1 | |
| Bill Tilden | 1 | |
| George Patrick Hughes | 1 | |
| André Merlin | 1 | |
| Emanuele Sertorio | 1 | |
| Giovanni Palmieri | 1 | |
| Wilmer Hines | 1 | |
| Frank Sedgman | 1 | |
| Budge Patty | 1 | |
| Fausto Gardini | 1 | |
| Lew Hoad | 1 | |
| Mervyn Rose | 1 | |
| Luis Ayala | 1 | |
| Barry MacKay | 1 | |
| Rod Laver | 1 | |
| Jan-Erik Lundqvist | 1 | |
| Tony Roche | 1 |
Table: List of Most Italian Open ATP Masters 1000 Titles Men, Rome, Tennis, Ranked.